Our scientists have shared their findings in articles in many of the world's leading
scientific publications. Articles in, peer-reviewed publications provide strong validation
from the scientific community of Maxygen's technologies. After reviewing this list of
selected recent publications, you may request a free reprint by clicking here.
Year: 2008
Year: 2007
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Title |
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Source |
| Brideau-Anderson A.D., Huang, X., Sun S.C. Chang, Chen T.T., Stark D, Sas IJ, Zadik L, Dawes G.N., Guptill D.R., McCord R, Govindarajan S, Roy A, Yang S, Gao J, Chen Y. H., Skartved N.J.O., Pedersen A. K., Lin D., Locher C. P., Rebbapragada I, Jensen A. D., Bass, S. H., Straight Nissen T. L., Viswanathan S, Foster G.R., Symons J. A., Patten P. A. | | Directed evolution of gene-shuffled IFN alpha molecules with activity profiles tailored for treatment of chronic viral diseases. | | Proceedings of the National Academy of Sciences U.S.A., May 15, 104(20):8269-8274 | | |
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Year: 2006
Year: 2005
Year: 2004
Year: 2003
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Title |
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Source |
| Perlman S., van den Hazel B., Christiansen J., Gram-Nielsen S., Jeppesen C.B., Andersen K.V., Halkier T., Okkels S. and Schambye H.T. | | Glycosylation of an N-terminal extension prologs the half-life and increases the in vivo activity of follicle stimulating hormone | | Journal of Clinical Endocrinology and Metabolism, July, 88(7): 3227-3235 | | | | Patten P.A. and Schellekens H. | | The immunogenicity of biopharmaceuticals | | In: Immunogenicity of Therapeutic Biological Products, Brown F., Mire-Sluis A.R. (eds.) Basel, Karger. Developments in Biologicals, 112:81-97 published April 2003 | | | | Masci P., Bukowski R., Patten P.A., Osborn B.L., and Borden E.C. | | New and modified interferon alfas: preclinical and clinical data | | Current Oncology Reports, March 2003, 5(2): 108-113 | | |
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Year: 2002
| Author(s) |
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Title |
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Source |
| Boesen, T.P., Soni, B., Schwartz, T. W. and Halkier, T. | | Single-chain Vascular Endothelial Growth Factor Variant with Antagonist Activity | | The Journal of Biological Chemistry, October 25, 277 (43): pp. 40335-40341 | | |
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Year: 2001
| Author(s) |
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Title |
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Source |
| Gustafsson C., Govindarajan S. and Emig R. | | Exploration of sequence space for protein engineering. | | Journal of Molecular Recognition, September-October, 14(5): 308-314. | | | | Kurtzman A.L., Govindarajan S., Vahle K., Jones J.T., Heinrichs V. and Patten P.A. | | Advances in directed protein evolution by recursive genetic recombination: applications to therapeutic proteins | | Current Opinion in Biotechnology, August, 12(4): 361-370 | | | | Kolkman J.A. and Stemmer W.P.C. | | Directed evolution of proteins by exon shuffling | | Nature Biotechnology, May, 19(5): 423-428 | | | | Ness J.E., Del Cardayre S.B., Minshull J., and Stemmer W.P.C. | | Molecular breeding: the natural approach to protein design | | Advances in Protein Chemistry, October 11, 2000, 55:261-292 | | |
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Year: 2000
| Author(s) |
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Title |
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Source |
| Yamamoto T., and Dean D.H. | | Insecticidal proteins produced by bacteria pathogenic to agricultural pests | | Entomopathogenic Bacteria: From Laboratory to Field Application, J.-F. Charles, A. Delecluse, C. Nielsen-Le Roux (eds.), Dordrecht ; Boston, MA : Kluwer Academic Publishers, October 2000. pp.81-100 | | | | Tobin M.B., Gustafsson C., and Huisman G.W. | | Directed evolution: the ‘rational’ basis for ‘irrational’ design | | Current Opinion in Structural Biology, August, 10(4): 421-427 | | | | Punnonen J., Whalen R.G., Patten P.A., and Stemmer W.P.C. | | Molecular breeding by DNA shuffling | | Science & Medicine, March/April, 7(2): 38-47 | | |
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Year: 1999
| Author(s) |
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Title |
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Source |
| Chang C.-C. J., Chen T. T., Cox B. W., Dawes G. N., Stemmer W. P. C., Punnonen J., Patten P. A. | | Evolution of a cytokine using DNA family shuffling | | Nature Biotechnology, August, 17(8): 793-797 | | |
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Year: 1998
| Author(s) |
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Title |
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Source |
| Crameri, A., Raillard, S. Bermudez, E., and Stemmer, W.P.C. | | DNA shuffling of a family of genes from diverse species accelerates directed evolution | | Nature, January 15, 391(6664): 288-291 | | |
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Year: 1997
| Author(s) |
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Title |
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Source |
| Patten, P. A., Howard, R. J., and Stemmer, W.P.C. | | Applications of DNA shuffling to pharmaceuticals and vaccines | | Current Opinion in Biotechnology, December, 8(6): 724-733 | | |
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